What’s The Deal With Fasting?

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Listen on Google Play MusicIntermittent fasting. Water fasting. Time restricted eating. Juice cleanses. Many of us have heard about these things, often knocking them as fads or extreme ways of living. However, there seems to be a lot of buzz lately about the benefits of fasting. So what does the science say? Well, you’re in the right place.

After hearing about the evidence behind time restricted feeding or intermittent fasting on Dr. Rhonda Patrick’s podcast and elsewhere, Aaron decided to try it out for himself. Alongside a regular sauna routine combined with an overall healthy, whole foods plant-based diet, he has seen profound benefits. From sleep quality to endurance gains, we’ve both felt the positive effects of eating our food within a 9 or 10 hour window during the day. But how does this actually work? What’s happening metabolically and physiologically to stimulate these effects? In true TFF What’s The Deal fashion, we set off to find out.

It’s been quite some time since we recorded a WTD episode, and that’s due to the immense amount of research and time it requires. With Aaron’s new kid on the block, changing jobs and moving, along with Jackson’s travel and school schedule, we simply didn’t have a ton of time to focus on this. But it’s definitely worth the wait; we covered everything from how fasting can potentially prevent disease at the cellular level, to how we feel it should be implemented in a practical fashion in everyday life. We zoom in to zoom out, and discuss this through an objective and evidence-based approach, so we hope you learn something new! It’s a bit of a longer episode, so hang in there, take a break if needed, and enjoy.

-Jackson and Aaron


Show Notes

Studies/resources referenced:

Found My Fitness (Dr. Rhonda Patrick): https://www.foundmyfitness.com/

Dr. Ray Cronise: http://hypothermics.com/home/

382 Day Fast:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2495396/pdf/postmedj00315-0056.pdf

 

Intermittent Fasting Meta Analysis:

http://www.annualreviews.org/doi/full/10.1146/annurev-nutr-071816-064634?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

 

Circadian Biology:

https://www.ncbi.nlm.nih.gov/pubmed/12015613?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946160/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388543/

https://www.ncbi.nlm.nih.gov/pubmed/20228939?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/19255424?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/23899596?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24360271?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/7985925?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/23817841?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/22811066?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/17805428?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/11405333?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/19271347?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/23899596?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24360271?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/20228939?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/12015613?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/19255424?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/7985925?dopt=Abstract

Gut Microbiota:

https://www.ncbi.nlm.nih.gov/pubmed/1528953?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/20122134?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24009397?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/21633181?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/17183312?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/25498959?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24009397?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/21633181?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/17183312?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/27188904?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/23847095?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/22378797?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24687809?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/22717075?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/23159341?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/21633181?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/27208092?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/25417104?dopt=Abstract

 

Modifiable Lifestyle Behaviors:

https://www.ncbi.nlm.nih.gov/pubmed/26411343?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/26819200?dopt=Abstract

http://cel.webofknowledge.com/InboundService.do?mode=FullRecord&customersID=atyponcel&IsProductCode=Yes&product=CEL&Init=Yes&Func=Frame&action=retrieve&SrcApp=literatum&SrcAuth=atyponcel&SID=2BSZLrGIiYTKfgPpU7t&UT=WOS%3A000369691500017

https://www.ncbi.nlm.nih.gov/pubmed/24950157?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24898236?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24918187?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/21664632?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/23199168?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24451608?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/22608008?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/27832862?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/22608008?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/27062219?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/26864365?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/24394729?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/23945417?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/20621406?dopt=Abstract

http://onlinelibrary.wiley.com/doi/10.1002/oby.20558/abstract;jsessionid=F5827D6CE2A9E32339B5CF3364DB56C2.f02t04

https://www.ncbi.nlm.nih.gov/pubmed/19645960?dopt=Abstract

http://www.smrv-journal.com/article/S1087-0792(09)00072-0/fulltext

http://cel.webofknowledge.com/InboundService.do?mode=FullRecord&customersID=atyponcel&IsProductCode=Yes&product=CEL&Init=Yes&Func=Frame&action=retrieve&SrcApp=literatum&SrcAuth=atyponcel&SID=4EOY7NjjuEeUBDwdlOV&UT=WOS%3A000253823400020

https://www.ncbi.nlm.nih.gov/pubmed/16227462?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/21127246?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/26864365?dopt=Abstract

 

Autophagy, Muscle Mass and Endurance:

http://genesdev.cshlp.org/content/21/22/2861.full

https://www.ncbi.nlm.nih.gov/pubmed/24560926

https://www.ncbi.nlm.nih.gov/pubmed/21030235

http://www.cell.com/abstract/S0092-8674(13)00645-4

http://www.cell.com/cell-stem-cell/abstract/S1934-5909(14)00151-9

https://www.ncbi.nlm.nih.gov/pubmed/27032109

https://www.ncbi.nlm.nih.gov/pubmed/26774472

https://www.ncbi.nlm.nih.gov/pubmed/2402168

https://www.ncbi.nlm.nih.gov/pubmed/25957282

http://jap.physiology.org/content/86/2/479.short

http://jap.physiology.org/content/110/1/236.short

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990190/

https://www.ncbi.nlm.nih.gov/pubmed/27737674

https://www.ncbi.nlm.nih.gov/pubmed/27550719


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